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Senior Investigator

Armin Raznahan, M.D., Ph.D.

Section on Developmental Neurogenomics (SDN)

Building 10 Room 4D-18
10 Center Drive
Bethesda MD 20892
Office: (301) 435-7927

Armin Raznahan, MD, PhD, is a child and adolescent psychiatrist, and Chief of the Section on Developmental Neurogenomics (SDN). His research combines neuroimaging, genomic and bioinformatic techniques to better understand the architecture of human brain development in health, and in neurogenetic disorders that increase risk for psychiatric symptoms. Dr. Raznahan completed his undergraduate and graduate training in London, UK (Medicine and pediatrics at King’s College University/ Hospital; psychiatry and the Maudsley Hospital), and then trained as a postdoctoral fellow with Drs. Jay Giedd and Judith Rapoport at the NIMH Intramural Research Program. Dr. Raznahan joined the NIH-Lasker Clinical Research Scholars Program in 2015, and became a tenured Senior Investigator at the NIMH IRP in 2020.

Dr. Raznahan is a member of the UK Royal College of Psychiatrists, the UK Royal College of Pediatrics and Child Health, and the American College of Neuropsychopharmacology (ACNP). He currently serves as an editor for the Journal of the American Academy of Child and Adolescent Psychiatry, NeuroImage, and Aperture. Dr. Raznahan also serves on the ACNP Diversity and Inclusion Task Force and the ACNP Membership Committee, the AXYS (Association for X- and Y-Chromosome Variations) Advisory Committee, the Organization for the Study of Sex Differences Council, and the French Autism and Neuro-Developmental Disorders Scientific Advisory Board. The Section of Developmental Neurogenomics has been recognized by awards from the NIMH Director (Outstanding Mentorship and Scientific Contributions), ACNP (Eva King-Killam Award for Translational Research) and the American Psychopathological Association (Robins-Guze Award).

The Section on Developmental Neurogenomics (SDN) is dedicated to better understanding the biology of childhood-onset neuropsychiatric disorders in ways that might ultimately help to improve disease prediction, detection, and treatment. Together with our collaborators, we work towards this goal in two mutually-informative ways.

First, we use large-scale neuroimaging datasets to study the architecture of brain development in healthy volunteers. By modeling how neuroimaging measures of the human brain vary with age, sex, and behavior in health, we hope to advance basic developmental neuroscience while also providing a data-driven way of selecting neuroimaging measures that should be prioritized for study in atypically developing groups.

Second, we use a “genetics-first” strategy to study the relationship between atypical brain development and neuropsychiatric symptoms. This effort involves gathering “deep-phenotypic” data (spanning measures of gene expression, brain structure/function, psychophysiology, cognition and behavior) in diverse genetic disorders which all increase risk for neuropsychiatric impairment. Guided by knowledge of typical development, we harness these clinical data to empirically dissect the diverse biological pathways that can contribute to the emergence of neuropsychiatric syndromes.

Cross-cutting themes of special interest within our Section include sex-differences, allometry, and structure-function relationships within the central nervous system.

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  • 1) Seidlitz J, Nadig A, Liu S, Bethlehem RAI, Vértes PE, Morgan SE, Váša F, Romero-Garcia R, Lalonde FM, Clasen LS, Blumenthal JD, Paquola C, Bernhardt B, Wagstyl K, Polioudakis D, de la Torre-Ubieta L, Geschwind DH, Han JC, Lee NR, Murphy DG, Bullmore ET, Raznahan A (2020)
  • Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders
  • Nat Commun 11, 3358.
  • 2) Liu S, Seidlitz J, Blumenthal JD, Clasen LS, Raznahan A (2020)
  • Integrative structural, functional, and transcriptomic analyses of sex-biased brain organization in humans
  • Proc Natl Acad Sci U S Ain press (e-pub ahead of print)
  • 3)Reardon PK, Seidlitz J, Vandekar S, Liu S, Patel R, Park MTM, Alexander-Bloch A, Clasen LS, Blumenthal JD, Lalonde FM, Giedd JN, Gur RC, Gur RE, Lerch JP, Chakravarty MM, Satterthwaite TD, Shinohara RT, Raznahan A (2018)
  • Normative brain size variation and brain shape diversity in humans
  • Science 3601222-1227.
  • 4)Raznahan A, Parikshak NN, Chandran V, Blumenthal JD, Clasen LS, Alexander-Bloch AF, Zinn AR, Wangsa D, Wise J, Murphy DGM, Bolton PF, Ried T, Ross J, Giedd JN, Geschwind DH (2018)
  • Sex-chromosome dosage effects on gene expression in humans
  • Proc Natl Acad Sci U S A 115, 7398-7403.
  • 5)Raznahan A, Lue Y, Probst F, Greenstein D, Giedd J, Wang C, Lerch J, Swerdloff R (2015)
  • Triangulating the sexually dimorphic brain through high-resolution neuroimaging of murine sex chromosome aneuploidies
  • Brain Struct Funct 220, 3581-93.
  • 6) Raznahan A, Shaw PW, Lerch JP, Clasen LS, Greenstein D, Berman R, Pipitone J, Chakravarty MM, Giedd JN. (2014)
  • Longitudinal four-dimensional mapping of subcortical anatomy in human development
  • Proc Natl Acad Sci USA, 111:1592–1597, PMID: 24474784.
  • 7) Raznahan A, Lee NR, Greenstein D, Wallace GL, Blumenthal JD, Clasen LS, Giedd JN. (2014)
  • Globally Divergent but Locally Convergent X- and Y-Chromosome Influences on Cortical Development
  • Cereb Cortex, PMID: 25146371.
  • 8) Raznahan A, Lue Y, Probst F, Greenstein D, Giedd J, Wang C, Lerch J, Swerdloff R. (2014)
  • Triangulating the sexually dimorphic brain through high-resolution neuroimaging of murine sex chromosome aneuploidies
  • Brain Struct Funct., PMID: 25146308.
  • 9) Raznahan A, Wallace GL, Antezana L, Greenstein D, Lenroot R, Thurm A, Gozzi M, Spence S, Martin A, Swedo SE, Giedd JN. (2013)
  • Compared to what? Early brain overgrowth in autism and the perils of population norms
  • Biol Psychiatry, 74:563–575 , PMID: 23706681.
  • 10) Raznahan A, Greenstein D, Lee NR, Clasen LS, Giedd JN. (2012)
  • Prenatal growth in humans and postnatal brain maturation into late adolescence
  • Proc Natl Acad Sci U S A. , 109:11366–11371, PMID: 22689983.
  • 11) Raznahan A, Shaw P, Lalonde F, Stockman M, Wallace GL, Greenstein D, Clasen L, Gogtay N, Giedd JN. (2011)
  • How does your cortex grow?
  • J Neurosci., 31:7174–7177, PMID: 21562281.
  • 12) Raznahan A, Lerch JP, Lee N, Greenstein D, Wallace GL, Stockman M, Clasen L, Shaw PW, Giedd JN. (2011)
  • Patterns of coordinated anatomical change in human cortical development: a longitudinal neuroimaging study of maturational coupling
  • Neuron, 72:873–884, PMID: 22153381.
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