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Senior Investigator

Daniel S. Reich, M.D., Ph.D.

Translational Neuroradiology Section

Division of Neuroimmunology and Neurovirology
Building 10 Room 5C103
10 Center Drive MSC 1400
Bethesda MD 20892-4128
Office: (301) 496-1801

Fax: (301) 402-0373

Daniel Reich – a neurologist and neuroradiologist – directs the Translational Neuroradiology Section in NINDS. In his clinical practice, he cares for patients with multiple sclerosis and other neurological diseases, and he also leads several clinical studies focusing on multiple sclerosis. Research in his lab focuses on the use of advanced MRI techniques to understand the sources of disability in multiple sclerosis and on ways of adapting those approaches for research trials and patient care. He is particularly interested in harnessing noninvasive imaging modalities to dissect biological mechanisms of tissue damage.

The major goal of research in my lab is to understand the pathobiology of multiple sclerosis using noninvasive or minimally invasive imaging methods – particularly magnetic resonance imaging (MRI). My lab develops and performs experiments with new MRI techniques, on state-of-the-art imaging equipment housed in the NIH Clinical Center, to elucidate the biological underpinnings of imaging abnormalities and to understand how such abnormalities relate to clinical disability. In addition to the human disease, we also study related animal models using similar techniques. Corollary goals of the research are to adapt new imaging techniques as biologically (and hopefully clinically) relevant outcome measures in both clinical trials and routine patient care, and to apply them to other inflammatory diseases of the central nervous system.

Staff Image
  • Omar Al-Louzi, M.D.
    Clinical Fellow

  • Melissa Arey, B.S.
    Office Manager

  • Erin Beck, M.D., Ph.D.
    Clinical Fellow

  • Govind Bhagavatheeshwaran, Ph.D.
    Staff Scientist

  • Lynn Daboul, B.S.
    Research Fellow

  • Maxime Donadieu, Ph.D.
    Postdoctoral Fellow

  • Stefano Filippini, M.D.
    Visiting Scholar

  • Hannah Kelly, B.S.
    Post baccalaureate Fellow

  • Hadar Kolb, M.D.
    Research Fellow

  • Amanda Lee, B.S.

  • Jing-Ping Lin, Ph.D.
    Postdoctoral Fellow

  • Mark Morrison, B.S.
    Post baccalaureate Fellow

  • Prasanna Parvathaneni, Ph.D.
    Postdoctoral Fellow

  • Yeajin Song, B.S.
    Laboratory Manager

  • 1) Lefeuvre J, Guy JR, Luciano NJ, Ha SK, Leibovitch E, Santin MD, Silva AC, Jacobson S, Lehéricy S, Reich DS, Sati P (2019)
  • The spectrum of spinal cord lesions in a primate model of multiple sclerosis
  • Mult Scler , in press. Epub 2019 Feb 7. PMID: 30730246, PMC6685769. 10.1177/1352458518822408
  • 2) Absinta M, Nair G, Monaco MC, Maric D, Lee N, Ha SK, Luciano N, Sati P, Jacobson S, Reich DS (2019)
  • The central vein sign in inflammatory demyelination: the role of collagen type I
  • Ann Neurol , 85:934-942. Epub 2019 Mar 7. PMID: 30847935, PMC6520117. 10.1002/ana.25461
  • 3) Cortese ICM, Muranski P, Enose-Akahata Y, Ha SK, Smith B, Monaco MC, Ryschewitsch C, Major EO, Ohayon J, Schindler MK, Beck ES, Reoma LB, Jacobson S, Reich DS, Nath A (2019)
  • Treatment of progressive multifocal leukoencephalopathy with pembrolizumab
  • New Engl J Med, 380:1597-1605. Epub 2019 Apr 10, . PMID: 30969503. PMC — in progress. 10.1056/NEJMo
  • 4) Sudarshana DM, Nair G, Dwyer JT, Dewey B, Steele SU, Wu T, Berkowitz BA, Koretsky AP, Cortese ICM, Reich DS (2019)
  • Manganese-enhanced MRI (MEMRI) of the brain in healthy volunteers
  • AJNR Am J Neuroradiol , 40:1309-1316. Epub 2019 Aug 1, PMID: 31371354. PMC6754109. 10.3174/ajnr.a6152
  • 5) Absinta M, Sati P, Masuzzo F, Nair G, Sethi VV, Kolb H, Ohayon J, Wu T, Cortese ICM, Reich DS (2019)
  • Chronic active multiple sclerosis lesions are destructive on serial MRI and associated with disability in vivo
  • JAMA Neurol , 76:1474-1483. Epub 2019 Aug 12, PMID: 31403674. PMC6692692. 10.1001/jamaneurol.201
  • 6) Lee NJ, Ha SK, Sati P, Absinta M, Nair G, Luciano NJ, Leibovitch EC, Yen CC, Rouault TA, Silva AC, Jacobson S, Reich DS (2019)
  • Potential role of iron in repair of inflammatory demyelinating lesions
  • J Clin Invest , 129:4365-4376. Epub 2019 Sep 9, PMC676324. 10.1172/JCI126809
  • 7) Werneburg S, Jung J, Kunjamma RB, Ha SK, Luciano NJ, Willis CM, Gao G, Biscola NP, Havton LA, Crocker SJ, Popko B, Reich DS, Schafer DP (2019)
  • Targeted complement inhibition at synapses prevents microglial synaptic engulfment and synapse loss in demyelinating disease
  • Immunity , 52:167-182. Epub 2019 Dec 26, PMID: 31883839. PMC6996144. 10.1016/j.immuni.2019.
  • 8) Absinta M, Sati P, Fechner A, Schindler MK, Nair G, Reich DS (2018)
  • Identification of chronic active multiple sclerosis lesions at 3T MRI
  • AJNR Am J Neuroradiol , 39:1233-1238. Epub 2018 May 3 , PMID: 29724768. PMC6039266. 10.3174/ajnr.A5660
  • 9) Lee NJ, Ha SK, Sati P, Absinta M, Luciano NJ, Lefeuvre JA, Schindler MK, Leibovitch EC, Ryu JK, Petersen MA, Silva AC, Jacobson S, Akassoglou K, Reich DS (2018)
  • Spatiotemporal distribution of fibrinogen in marmoset and human inflammatory demyelination
  • Brain, 141(6), 1637-1649
  • 10) Luciano NJ, Sati P, Nair G, Guy JR, Ha SK, Absinta M, Chiang WY, Leibovitch EC, Jacobson S, Silva AC, Reich DS (2017)
  • Utilizing 3D Printing Technology to Merge MRI with Histology: A Protocol for Brain Sectioning
  • J Vis Exp, 118, e54780
  • 11) Guy JR, Sati P, Leibovitch E, Jacobson S, Silva AC, Reich DS (2016)
  • Custom fit 3D-printed brain holders for comparison of histology with MRI in marmosets
  • J Neurosci Methods, 257, 257:55-63
  • 12) *Absinta M, *Vuolo L, Rao A, Nair G, Sati P, Cortese ICM, Ohayon J, Fenton K, Reyes-Mantilla MI, Maric D, Calabresi PA, Butman JA, Pardo CA, Reich DS. (2015)
  • Gadolinium-based MRI characterization of leptomeningeal inflammation in multiple sclerosis.
  • Neurology, Epub 2015 Apr 17. PMID: 25888557. PMC4501940., 85:18-28
  • 13) Guy JR, Sati P, Leibovitch E, Jacobson S, Silva AC, Reich DS. (2015)
  • Custom fit 3D-printed brain holders for comparison of histology with MRI in marmosets.
  • J Neurosci Methods, Epub 2015 Sep 10.
  • 14) Xia Z, White C, Owen E, von Korff A, Clarkson S, McCabe C, Cimpean M, Winn P, Hoesing A, Steele S, Cortese ICM, Chitnis T, Weiner H, Reich DS, Chibnik L, De Jager P. (2015)
  • GEMS project: a platform to investigate multiple sclerosis risk
  • Ann Neurol, in press, PMC Journal – in progress
  • 15) Sweeney EM, Shinohara RT, Dewey BE, Schindler MK, Muschelli J, Reich DS, Crainiceanu CM, Eloyan A. (2015)
  • Relating multi-sequence longitudinal intensity profiles and clinical covariates in incident multiple sclerosis
  • Neuroimage Clin , Epub 2015 Nov 11
  • 16) Sati P, Thomasson D, Li N, Pham DL, Biassou N, Reich DS, Butman JA. (2014)
  • Rapid, high-resolution, whole-brain, susceptibility-based MRI of multiple sclerosis
  • Mult Scler , Epub 2014 Mar 17. PMID: 24639479. PMC4167170., 20:1464-1470
  • 17) Liu W, Nair G, Vuolo L, Bakshi A, Massoud R, Reich DS, Jacobson S (2014)
  • In-vivo imaging of spinal cord atrophy in neuroinflammatory diseases
  • Ann Neurol, Epub 2014 Jul 1. PMID: 25042583. PMC4165784. , 76:370-378
  • 18) *Absinta M, *Nair G, Filippi M, Ray-Chaudhury A, Reyes-Mantilla MI, Pardo CA, Reich DS. (2014)
  • Postmortem MRI to guide the pathological cut: Individualized, 3D-printed cutting boxes for fixed brains.
  • J Neuropath Exp Neurol , Epub 2014 Aug. PMID: 25007244. PMC4144036, 73:780-788
  • 19) Shinohara RT, Sweeney EM, Goldsmith J, Shiee N, Mateen FJ, Calabresi PA, Jarso S, Pham DL, Reich DS, Crainiceanu CM. (2014)
  • Statistical normalization techniques for magnetic resonance imaging.
  • Neuroimage Clin , Epub 2014 Aug 15. PMID: 25379412. PMC4215426., 6:9-19
  • 20) Gaitán MI, de Alwis MP, Sati P, Nair G, Reich DS (2013)
  • Multiple sclerosis shrinks intralesional, and enlarges extralesional, brain parenchymal veins
  • Neurology, Epub 2012 Dec 19. PMID: 23255828. PMC3589186, 80:145-151
  • 21) *Leibovitch E, *Wohler JE, Motanic K, McCormick M, Harberts E, Gaitán MI, Maggi P, Cummings Macri SM, Westmoreland S, Silva A, Reich DS, Jacobson S. (2013)
  • Novel marmoset (Callithrix jacchus) model of human Herpesvirus 6A and 6B infections: immunologic, virologic and radiologic characterization
  • PLoS Pathogens, Epub 2013 Jan 31. PMID: 23382677. PMC3561285, 9:e1003138
  • 22) Sweeney EM, Shinohara RT, Shiee N, Mateen F, Chudgar A, Cuzzocreo J, Calabresi PA, Pham DL, Reich DS, Crainiceanu C (2013)
  • OASIS is automated statistical inference for segmentation, with applications to multiple sclerosis lesion segmentation in MRI
  • Neuroimage Clin, Epub 2013 Mar 15. PMID: 24179794. PMC3777691, 2:402-413
  • 23) Nair G, Absinta M, Reich DS (2013)
  • Optimized T1-MPRAGE sequence for better visualization of spinal cord MS lesions at 3T
  • AJNR Am J Neuroradiol, Epub: 2013 Jun 13. PMID: 23764721. PMC4278432, 201334:2215-2222
  • 24) Absinta M, Sati P, Gaitán MI, Maggi P, Cortese ICM, Filippi M, Reich DS. (2013)
  • 7T phase imaging of acute MS lesions: A new window into the inflammatory process.
  • Ann Neurol, Epub 2013 Jun 28. PMID: 23813441. PMC3812397, 74:669-678
  • 25) Jones BC, Nair G, Shea CD, Crainiceanu CM, Cortese ICM, Reich DS. (2013)
  • Quantification of multiple-sclerosis-related brain atrophy in two heterogeneous MRI datasets using mixed-effects modeling.
  • Neuroimage Clin, Epub 2013 Aug 30. PMID: 24179861. PMC3791279, 3:171-179
  • 26) Sweeney EM, Shinohara RT, Shea CD, Reich DS, Crainiceanu CM (2013)
  • Automatic lesion incidence estimation and detection using multi-modality longitudinal MRIs
  • AJNR Am J Neuroradiol, Epub 2012 Jul 5. PMID: 22766673. PMC3554794, 34:68-73
  • 27) Sati P, Silva AC, van Gelderen P, Gaitán MI, Wohler JE, Jacobson S, Duyn JH, Reich DS (2012)
  • In vivo quantification of T2* anisotropy in white matter fibers in marmoset monkeys
  • Neuroimage, Epub 2011 Aug 27. PMID: 21906687. PMC3230780, 59:979-985
  • 28) Wood ET, Ronen I, Techawiboonwong A, Jones CK, Barker PB, Calabresi PA, Harrison DM, Reich DS. (2012)
  • Investigating axonal damage in multiple sclerosis by diffusion tensor spectroscopy
  • J Neurosci, Epub 2012 Mar 21. PMID: 22573688. PMC3360480, 32:6665-6669
  • 29) Shinohara RT, Goldsmith J, Mateen F, Crainiceanu CM, Reich DS (2012)
  • Predicting breakdown of the blood-brain barrier in multiple sclerosis without contrast agents
  • AJNR Am J Neuroradiol, Epub 2012 Mar 22. PMID: 22442041. PMC3555688, 33:1586-1590
  • 30) Sati P, George IC, Shea CD, Gaitán MI, Reich DS (2012)
  • FLAIR*: A combined MR contrast technique for visualizing white matter lesions and parenchymal veins
  • Radiology , Epub 2012 Oct 16. PMID: 23074257. PMC3504317, 265:926-932
  • 31) Gaitán MI, Shea CD, Evangelou IE, Stone RD, Fenton KM, Bielekova B, Massacesi L, Reich DS (2011)
  • Evolution of the blood­-brain barrier in newly forming multiple sclerosis lesions
  • Ann Neurol, Epub 2011 Jun 27. PMID: 21710622. PMC3143223, 70:22-29
  • 32) Shiee N, Bazin P-L, Ozturk A, Calabresi PA, Reich DS, Pham D (2010)
  • A topology-preserving approach to the segmentation of brain images with multiple sclerosis lesions
  • Neuroimage, PMID: 19766196. PMC2806481, 49:1524-1535
  • 33) Petrou M, Foerster BR, Reich DS (2009)
  • Translational research in radiology: challenges and role in a patient-based practice
  • Acad Radiol, PMID: 19345901. PMC2775713, 16:593-596
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