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Senior Investigator

David M. Lovinger, Ph.D.

Building 12420 Room 158H
12420 Parklawn Dr, MSC 8115
Bethesda MD 20892-8115
Office: (301) 443-2445
Lab: (301) 443-2445
Fax: (301) 480-1734

Dr. Lovinger received a B.A. in Psychology from the University of Arizona in 1981 and a Ph.D. in Psychology from Northwestern University in 1987. At Northwestern, he worked with Dr. Aryeh Routtenberg studying the roles of Protein Kinase C and its substrate, the GAP-43/F1 protein, in hippocampal long-term potentiation. His postdoctoral research at the NIAAA focused on the effects of alcohol on ligand-gated ion channels. In 1991 Dr. Lovinger moved to the Vanderbilt University School of Medicine as an Assistant Professor, where in 1998 he rose to the rank of Professor. At Vanderbilt he was also the Deputy Director for Biomedical Science and the Director of the Neuroscience Core within the Kennedy Center. Dr. Lovinger joined the NIAAA in 2001 as a Senior Investigator and Chief of the Laboratory of Integrative Neuroscience. His laboratory is currently studying the modulation and plasticity of synaptic transmission at corticostriatal synapses and the mechanisms by which abused substances effect synaptic transmission.

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  • 1) Mathur, B.N., Capik, N.A., Alvarez, V.A. and Lovinger, D.M. (2011)
  • Serotonin-mediated long-term depression at corticostriatal synapse
  • J. Neurosci, 31(20), 7402-11
  • 2) E. Bello Gay, Y. Mateo, D.M. Gelman, D. Noain, J.H. Shin, C.M. Backman, M.J. Low, V.A. Alvarez, D.M. Lovinger and M. Rubinstein (2011)
  • Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors
  • Nature Neuroscience, 14, 1033-8
  • 3) Yin, H.H., Mulcare, S.P., Hilario, M.R.F., Clouse, E., Holloway, T., Davis, M.I., Hansson, A.C., Lovinger, D.M. and Costa, R.M. (2009)
  • Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill
  • Nat. Neurosci, 12(3), 333-341
  • 4) Adermark, L. and Lovinger, D.M. (2009)
  • Frequency-dependent inversion of net striatal output by endocannabinoid-dependent plasticity at different synaptic inputs
  • J. Neurosci, 29(5), 1375-1380
  • 5) Ronesi, J, Lovinger, DM (2005)
  • Induction of striatal long-term synaptic depression by moderate frequency activation of cortical afferents in rat.
  • Journal of Physiology, 562 (Pt.1), 245-256
  • 6) Ronesi, J., Gerdeman, G.L., Lovinger, D.M. (2004)
  • Disruption of endocannabinoid release and striatal long-term depression by postsynaptic blockade of endocannabinoid membrane transport.
  • Journal of Neuroscience, 24(7), 1673-1679
  • 7) M.I Davis, J. Ronesi, D.M. Lovinger (2003)
  • A predominant role for inhibition of the adenylate cyclase PKA pathway in ERK activation by CB1 receptors in N1E-115 neuroblastoma cells.
  • Journal of Biological Chemistry, 278(49), 48973-48980
  • 8) Partridge, J. and Lovinger, D.M. (2002)
  • Nicotinic Acetylcholine Receptors Interact with Dopamine in Induction of Striatal Long-Term Depression.
  • J. Neurosci., 22, 2541-2549
  • 9) Gerdeman, G. and Lovinger, D.M. (2002)
  • Postsynaptic endocannabinoid release is necessary for long-term depression in the striatum.
  • Nature Neuroscience, 5, 446-451
  • 10) Sung, K-W., Choi, S. and Lovinger, D.M. (2001)
  • Activation of group I metabotropic glutamate receptors is necessary for induction of long-term synaptic depression at striatal synapses.
  • J. Neurophysiol., 86, 2405-2412
  • 11) Gerdeman, G.L. and Lovinger, D.M. (2001)
  • The CB1 cannabinoid receptor inhibits synaptic release of glutamate in rat dorsolateral striatum.
  • J. Neurophysiol., 85, 468-471
  • 12) Lovinger, D.M., Sung, K-W. and Zhou, Q. (2000)
  • Ethanol and trichloroethanol increase the probability of opening of 5-HT3 receptor-channels in NCB-20 neuroblastoma cells.
  • Neuropharm., 39, 561-570
  • 13) Lovinger, D., Akers, R., Nelson, R., Barnes, C., McNaughton, B. and Routtenberg, A. (1985)
  • A selective increase in hippocampal protein F1 phosphorylation directly related to three day growth of long-term synaptic enhancement.
  • Brain Res., 343, 137-148
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