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Senior Investigator

Elliot A Stein, Ph.D.

Neuroimaging Research Branch

Room 07A711A
251 Bayview Blvd Suite 200
Baltimore MD
Office: 443-740-2650
Lab: 443-740-2650
Fax: 443-740-2753

Elliot A. Stein, Ph.D., Chief, Neuroimaging Research Branch, NIDA

Post-doctoral training: Behavioral Neurobiology, California Institute of Technology (advisor Dr. James Olds)

Ph. D.: Neurophysiology, University of Maryland, School of Medicine

B.A.: Biology, Quinnipiac University

Dr. Stein’s research is directed at understanding the neurobiological mechanisms underlying human drug use and addiction. Using a number of MRI based (e.g. fMRI, MR spectroscopy, functional connectivity, DTI) and PET (dopamine, serotonin systems) imaging techniques in both human and animal models, his lab aims to understand how both acute and chronic drug administration alters neuronal and cognitive processing and subsequent behavioral outcome. His human imaging research, centered mostly on cocaine and nicotine dependence, emphasizes the importance of cognitive, affective, personality and environmental interactions with the drug’s pharmacological properties. More recent studies are examining these properties in marijuana, ecstasy and methamphetamine users. Drug using individuals and healthy matched control subjects are employed to test specific hypotheses related to such cognitive constructs as attention, reward processing, craving, affect, decision making and response inhibition. The consequences of chronic drug use on systems level neuroplasticity are examined longitudinally during drug withdrawal and treatment regimens. Together with collaborators, the lab has begun to examine how specific individual genetic polymorphisms help explain the group variance imaging endophenotypes to better understand trait related predisposition and hopefully, treatment outcome. Finally, rodent and non-human primate imaging models are employed to address the biophysical bases of the fMRI signal and, using chronic drug use models unavailable in human research, better understand where and how various neuropharmacological manipulations alter local and circuit level neuronal functions. The long-term goal of this research is to develop more efficacious strategies to both treat existing and help prevent future drug use in high risk populations.

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  • 1) Belcher AM, Yen CC, Notardonato L, Ross TJ, Volkow ND, Yang Y, Stein EA, Silva AC, Tomasi D (2016)
  • Functional Connectivity Hubs and Networks in the Awake Marmoset Brain
  • Front Integr Neurosci, 10, 9
  • 2) Zhang X, Salmeron BJ, Ross TJ, Gu, H, Geng, X, Yang Y and Stein EA (2011)
  • Anatomical differences and network characteristics underlying smoking cue reactivity
  • NeuroImage, 54, 131-41
  • 3) Tang, Y-Y, Lu, Q, Geng, X, Stein, EA, Yang, Y, Posner, MI (2010)
  • Short-term meditation induces white-matter changes in the anterior cingulate
  • Proc. Nat’l Acad Sci (USA), 107, 15649-52
  • 4) 674-7 (2010)
  • Smoking and schizophrenia independently and additively reduce white matter integrity between striatum and frontal cortex
  • Zhang, X, Stein, EA, and Hong, LE, Biological Psychiatry , 68
  • 5) Hong, LE, Hodgkinson, CA, Yang, Y, Sampath, H, Ross, TJ, Buchholz, B, Salmeron, BJ, Srivastava, V, Thaker, GK, Goldman, D, and Stein, EA (2010)
  • A Genetically modulated cingulate circuit supports human nicotine addiction
  • Proc. Nat’l Acad Sci (USA) , 107, 13509-14
  • 6) Spinelli, S., Chefer, S., Carson, R.E., Jagoda, E., Lang, L., Heilig, M., Barr, C.S., Suomi, S., Higley, J.D., Stein, E.A (2010)
  • Effects of early-life stress on 5-HT1A receptors in juvenile Rhesus monkeys measured by Positron Emission Tomography
  • Biological Psychiatry , 67, 1146-1153
  • 7) Gu, H, Salmeron, BJ, Ross, TJ, Geng, X, Zhan, W, Stein, EA and Yang, Y (2010)
  • Mesocorticolimbic circuits are impaired in chronic cocaine users as demonstrated by resting-state functional connectivity
  • NeuroImage, 53, 593-601
  • 8) Spinelli, S, Chefer, S, Suomi, S J, Higley, D, Barr, CS, and Stein, EA (2009)
  • Early life stress induces long-term morphological changes in primate brain
  • Arch Gen Psych, 66, 658-665
  • 9) Hahn B, Ross TJ, Wolkenberg F, Huestis MA and Stein EA (2009)
  • Performance effects of nicotine during selective attention, divided attention and simple stimulus detection: an fMRI study
  • Cerebral Cortex, 19, 1990-2000
  • 10) Waltz JA, Schweitzer JB, Gold JM, Kurup PK, Ross TJ, Jo Salmeron B, Rose EJ, McClure SM, Stein EA (2009)
  • Patients with Schizophrenia have a reduced neural response to both unpredictable and predictable primary reinforcers
  • Neuropsychopharmacology, 34, 1567-77
  • 11) Hong, LE, Gu, H, Yang, Y, Ross, TJ, Salmeron, BJ, Buchholz, B, Thaker, GK, Stein, EA (2009)
  • Association of nicotine addiction and nicotine's actions with separate cingulate cortex functional circuits.
  • Archives Gen Psychiatry, 66, 431-441
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