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Senior Investigator

Jonathan L Katz, Ph.D.

Psychobiology Section

Room 06A711A
251 Bayview Boulevard Suite 200
Baltimore MD 21224
Office: 443-740-2582
Lab: 443-740-2582
Fax: 443-740-2829

Jonathan L. Katz, Ph.D., Chief, Psychobiology Section, NIDA.

Post-doctoral Training - Psychobiology Laboratory, Harvard Medical School (advisor: Dr. W. H. Morse)

Ph. D. - Department of Psychology, University of Maryland (thesis advisor: Dr. James E. Barrett)

B.S. - Psychology, University of Maryland

The scope of research in Dr. Katz’s laboratory is to examine the pharmacological mechanisms that underlie the behavioral effects of abused drugs that are involved in their abuse liability. The research is focused on CNS molecular targets that substantially modify various behavioral effects that predict abuse liability, such as the self-administration of drugs or assessments of their subjective effects, and developed specific hypotheses regarding these. Highly selective compounds are used to characterization actions at these targets. The laboratory is specifically interested in elucidating how actions within the CNS are transduced into reinforcing effects that lead to drug abuse, with a primary focus on stimulant drugs. The research program is currently studying the roles of the dopamine transport system and several other targets, including sigma receptors, that modulate the effects of cocaine. In addition, they are also working toward the discovery of novel agents that may serve as leads for the discovery of compounds effective in the medical treatment of drug abuse or several other neuropsychiatric disorders.

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  • 1) Katz JL, Hiranita T, Hong WC, Job MO, McCurdy CR (2017)
  • A Role for Sigma Receptors in Stimulant Self-Administration and Addiction
  • Handb Exp Pharmacol, 2017 Jan 22. doi: 10.1007/164_2016_94. [Epub ahead
  • 2) Katz JL, Hiranita T, Kopajtic TA, Rice KC, Mesangeau C, Narayanan S, Abdelazeem AH, McCurdy CR (2016)
  • Blockade of Cocaine or σ Receptor Agonist Self Administration by Subtype-Selective σ Receptor Antagonists
  • J Pharmacol Exp Ther, 2016 Jul;358(1):109-24. doi: 10.1124/jpet.116.2327
  • 3) Hong WC, Kopajtic TA, Xu L, Lomenzo SA, Jean B, Madura JD, Surratt CK, Trudell ML, Katz JL (2016)
  • 2-Substituted 3β-Aryltropane Cocaine Analogs Produce Atypical Effects without Inducing Inward-Facing Dopamine Transporter Conformations
  • J Pharmacol Exp Ther, 2016 Mar;356(3):624-34. doi: 10.1124/jpet.115.2307
  • 4) Freyberg Z, Sonders MS, Aguilar JI, Hiranita T, Karam CS, Flores J, Pizzo AB, Zhang Y, Farino ZJ, Chen A, Martin CA, Kopajtic TA, Fei H, Hu G, Lin YY, Mosharov EV, McCabe BD, Freyberg R, Wimalasena K, Hsin LW, Sames D, Krantz DE, Katz JL, Sulzer D, Javitch JA (2016)
  • Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain
  • Nat Commun, 2016 Feb 16;7:10652. doi: 10.1038/ncomms10652
  • 5) Soto PL, Hiranita T, Xu M, Hursh SR, Grandy DK, Katz JL (2016)
  • Dopamine D2-Like Receptors and Behavioral Economics of Food Reinforcement
  • Neuropsychopharmacology, 2016 Mar;41(4):971-8. doi: 10.1038/npp.2015.223. E
  • 6) Reith ME, Blough BE, Hong WC, Jones KT, Schmitt KC, Baumann MH, Partilla JS, Rothman RB, Katz JL (2015)
  • Behavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporter
  • Drug Alcohol Depend, 2015 Feb 1;147:1-19. doi: 10.1016/j.drugalcdep.201
  • 7) Kohut SJ, Hiranita T, Hong SK, Ebbs AL, Tronci V, Green J, Garcés-Ramírez L, Chun LE, Mereu M, Newman AH, Katz JL, Tanda G (2014)
  • Preference for distinct functional conformations of the dopamine transporter alters the relationship between subjective effects of cocaine and stimulation of mesolimbic dopamine
  • Biol Psychiatry, 2014 Nov 15;76(10):802-9. doi: 10.1016/j.biopsych.
  • 8) Hiranita T, Wilkinson DS, Hong WC, Zou MF, Kopajtic TA, Soto PL, Lupica CR, Newman AH, Katz JL (2014)
  • 2-isoxazol-3-phenyltropane derivatives of cocaine: molecular and atypical system effects at the dopamine transporter
  • J Pharmacol Exp Ther, . 2014 May;349(2):297-309. doi: 10.1124/jpet.113.2
  • 9) Soto PL, Hiranita T, Grandy DK, Katz JL (2014)
  • Choice for response alternatives differing in reinforcement frequency in dopamine D2 receptor mutant and Swiss-Webster mice
  • Psychopharmacology (Berl), ). 2014 Aug;231(16):3169-77. doi: 10.1007/s00213-0
  • 10) Slezak JM, Ricaurte GA, Tallarida RJ, Katz JL (2014)
  • Methylphenidate and impulsivity: a comparison of effects of methylphenidate enantiomers on delay discounting in rats
  • Psychopharmacology (Berl), 2014 Jan;231(1):191-8. doi: 10.1007/s00213-013-322
  • 11) Slezak JM, Ricaurte GA, Tallarida RJ, Katz JL (2014)
  • Methylphenidate and impulsivity: a comparison of effects of methylphenidate enantiomers on delay discounting in rats
  • Psychopharmacology (Berl), 2014 Jan;231(1):191-8. doi: 10.1007/s00213-013-322
  • 12) Hiranita T, Kohut SJ, Soto PL, Tanda G, Kopajtic TA, Katz JL (2014)
  • Preclinical efficacy of N-substituted benztropine analogs as antagonists of methamphetamine self-administration in rats
  • J Pharmacol Exp Ther, 2014 Jan;348(1):174-91. doi: 10.1124/jpet.113.2082
  • 13) Hiranita T, Mereu M, Soto PL, Tanda G, Katz JL (2013)
  • Self-administration of cocaine induces dopamine-independent self-administration of sigma agonists
  • Neuropsychopharmacology, 2013 Mar;38(4):605-15. doi: 10.1038/npp.2012.224.
  • 14) Slezak JM, Katz JL (2013)
  • An influence of delayed reinforcement on the effectiveness of psychostimulants to enhance indices of attention under a five-choice serial reaction time procedure in male rats
  • Exp Clin Psychopharmacol, 2013 Oct;21(5):355-62. doi: 10.1037/a0033726
  • 15) Hiranita T, Soto PL, Kohut SJ, Kopajtic T, Cao J, Newman AH, Tanda G, Katz JL (2011)
  • Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors
  • J Pharmacol Exp Ther, 2011 Nov;339(2):662-77. doi: 10.1124/jpet.111.1850
  • 16) Soto PL, Grandy DK, Hursh SR, Katz JL (2011)
  • Behavioral economics of food reinforcement and the effects of prefeeding, extinction, and eticlopride in dopamine D2 receptor mutant mice
  • Psychopharmacology (Berl) , 2011 Jun;215(4):775-84. doi: 10.1007/s00213-011-21
  • 17) Koffarnus MN, Katz JL (2011)
  • Response requirement and increases in accuracy produced by stimulant drugs in a 5-choice serial reaction-time task in rats.
  • Psychopharmacology (Berl), 2011 Feb;213(4):723-33. doi: 10.1007/s00213-010-20
  • 18) Krasnova IN, Li SM, Wood WH, McCoy MT, Prabhu VV, Becker KG, Katz JL, Cadet JL. (2008)
  • Transcriptional responses to reinforcing effects of cocaine in the rat hippocampus and cortex
  • Genes Brain Behav, 2008 Mar;7(2):193-202, Epub 2007 Jul 19
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