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Investigator

Priyanka Narayan, Ph.D.

Genetics & Biochemistry Branch
Building 10 Room 9N311
10 Center Drive
Bethesda MD 20814
Office: 301-435-2373


Priyanka.narayan@nih.gov

Dr. Priyanka Narayan joined NIDDK and NINDS in 2019 following completion of a postdoctoral fellowship at the Picower Institute at MIT and at the Whitehead Institute of Biomedical Research. Prior to that, Dr. Narayan earned her Ph.D. in 2012 from the University of Cambridge and her B.S. from Stanford University in 2008. Her research interests lie in uncovering the molecular underpinnings of neurodegenerative disease risk and progression.



Dr. Narayan studies the mechanisms of risk and resilience to neurodegenerative diseases. Neurodegenerative diseases like Alzheimer’s disease are a growing public health concern. The extended and devastating course of these diseases, the increasing patient population, and the lack of therapeutic options all contribute to this pressing public health crisis. Dr. Narayan’s lab studies the ways in which genetic and environmental factors alter fundamental cellular pathways to increase susceptibility or improve resilience to neurodegenerative diseases like Alzheimer’s disease. The lab is pursuing these scientific questions with the ultimate goal of identifying novel therapeutic or preventative mechanisms for neurodegenerative diseases. The research combines techniques from biochemistry, genetic screening, and neurobiology in human induced pluripotent stem cell-derived tissues.

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  • Linling Cheng
    Post baccalaureate Fellow

  • Zachary March
    Postdoctoral Fellow

  • Cassandra Small
    Post baccalaureate Fellow

  • Alessia Stewart
    Post baccalaureate Fellow

  • Linda Yang
    Lab/Scientific Manager

  • 1) Narayan P, Ehsani S, Lindquist S (2020)
  • Combating neurodegenerative disease with chemical probes and model systems
  • Nat Chem Biol , (2014 Nov) 10:911-20
  • 2) Narayan P, Orte A, Clarke RW, Bolognesi B, Hook S, Ganzinger KA, Meehan S, Wilson MR, Dobson CM, Klenerman D (2016)
  • The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β(1-40) peptide
  • Nat Struct Mol Biol , (2011 Dec 18) 19:79-83
  • 3) Narayan P, Holmström KM, Kim DH, Whitcomb DJ, Wilson MR, St George-Hyslop P, Wood NW, Dobson CM, Cho K, Abramov AY, Klenerman D (2014)
  • Rare individual amyloid-β oligomers act on astrocytes to initiate neuronal damage
  • Biochemistry, (2014 Apr 22) 53:2442-53
  • 4) Narayan P, Ganzinger KA, McColl J, Weimann L, Meehan S, Qamar S, Carver JA, Wilson MR, St George-Hyslop P, Dobson CM, Klenerman D (2013)
  • Single molecule characterization of the interactions between amyloid-β peptides and the membranes of hippocampal cells
  • J Am Chem Soc , (2013 Jan 30) 135:1491-8
View Pubmed Publication