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Senior Investigator and Stroke Branch Chief

Rebecca F. Gottesman, M.D., Ph.D.

Stroke Branch


BG 10 RM B1D733
10 Center Dr MSC 3700
Bethesda MD 20814
Office: 301-435-9321
rebecca.gottesman@nih.gov

Dr. Rebecca Gottesman joined the NINDS as the Chief of the Stroke Branch in May 2021. In addition to the Branch, she is also Chief of the Stroke, Cognition and Neuroepidemiology Section. Prior to NINDS, Dr. Gottesman was an investigator at The Johns Hopkins University where she made significant research contributions to understanding the cognitive impacts of stroke and other vascular disease, as well as short- and long-term associations between vascular risk factors, vascular disease, and dementias.


Degree

  • MD; Columbia University College of Physicians and Surgeons (2000)
  • PhD; Johns Hopkins Bloomberg School of Public Health (2007)
Residencies

  • Neurology; Johns Hopkins University School of Medicine (2004)
Fellowships

  • Vascular Neurology; Johns Hopkins University School of Medicine (2006)
Board Certifications

  • American Board of Psychiatry And Neurology (Neurology) (2005)
  • American Board of Psychiatry and Neurology (Vascular Neurology) (2008)



Vascular contributions to cognitive impairment and dementia (VCID): Dr. Gottesman studies modifiable risk factors for cognitive decline and dementia. Through large epidemiologic cohorts, such as the Atherosclerosis Risk in Communities (ARIC) study, she studies the association between vascular risk factors, especially in midlife, and cognitive decline and dementia. Using neuroimaging (with brain MRI and amyloid PET), she studies the mechanism of a vascular impact on cognition, dementia, and Alzheimer's disease.

Post-stroke cognitive impairment and dementia. (PSCID): As part of the DISCOVERY study (Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on Recovery), which is a large cohort currently recruiting patients with stroke (ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage) across 30 U.S. sites, Dr. Gottesman and her team will evaluate the association between stroke and dementia, with a focus on disparities populations.

Cerebral small vessel disease: Dr. Gottesman studies risk factors for, progression of, and outcomes related to cerebral small vessel disease, in clinical cohorts as well as population-based studies, using neuroimaging and cognitive assessment.

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  • 1. Johansen MC, Nyquist P, Sullivan K, Fornage M, Gottesman RF, Becker DM. Cerebral small-vessel disease in individuals with a family history of coronary heart disease: the Atherosclerosis Risk in Communities Study. Neuroepidemiology; 2021: online ahead of print.
  • 2. Walker KA, Chen J, Zhang J, Fornage M, Yang Y, Zhou L, Grams ME, Tin A, Daya N, Hoogeveen RC, Wu A, Sullivan KJ, Ganz P, Zeger SL, Gudmundsson EF, Emilsson V, Launer LJ, Jennings LL, Gudnason V, Chatterjee N, Gottesman RF, Mosley TH, Boerwinkle E, Ballantyne CM, Coresh J. Large-scale plasma proteomic analysis identifies proteins and pathways associated with dementia risk. Nature Aging; 2021: online ahead of print.
  • 3. Rost NS, Meschia JF, Gottesman R, Wruck L, Helmer K, Greenberg SM. Cognitive impairment and dementia after stroke: design and rationale for the DISCOVERY study. Stroke; 2021: online ahead of print.
  • 4. Johansen MC, Gottesman RF, Kral BG, Vaidya D, Yanek LR, Becker LC, Becker DM, Nyquist P. Association of coronary artery atherosclerosis with brain white matter hyperintensity. Stroke; 2021: online ahead of print.
  • 5. Levine DA, Gross AL, Briceno EM, Tilton N, Giordani BJ, Sussman JB, Hayward RA, Burke JF, Hingtgen S, Elkind MSV, Manly JJ, Gottesman RF, Gaskin DJ, Sidney S, Sacco RL, Tom SE, Wright CB, Yaffe K, Galecki AT. Sex differences in cognitive decline among US adults. JAMA Network Open. 2021; 4(2):e210169.
  • 6. Palta P, Sharrett AR, Gabriel KP, Gottesman RF, Folsom AR, Power MC, Evenson KR, Jack CR Jr, Knopman DS, Mosley TH, Heiss G. A prospective analysis of leisure-time physical activity in mid-life and beyond and brain damage on MRI in older adults. Neurology; 2021: 96(7): e964-e974.
  • 7. Sullivan KJ, Ranadive R, Su D, Neyland BR, Hughes TM, Hugenschmidt CE, Lockhart SN, Wong DF, Jack Jr CR, Gottesman RF, Mosley Jr TH, Griswold ME, Windham BG. Imaging-based indices of neuropathology and gait speed decline in older adults: The Atherosclerosis Risk in Communities Study. Brain Imaging and Behavior; 2021; Epub ahead of print.
  • 8. Liu C, Roth DL, Gottesman RF, Sheehan OC, Blinka MD, Howard VJ, Judd SE, Cushman M. Change in Life’s Simple 7 measure of cardiovascular health after incident stroke: The REGARDS study. Stroke; 2021; 52(3): 878-886.
  • 9. Johansen MC, Mosley TH, Knopman DS, Wong DF, Wagenknecht LE, Ndumele C, Shah AM, Solomon SD, Gottesman RF. The associations between atrial cardiopathy and cerebral amyloid: The ARIC-PET study. JAHA; 2020: 9(24): e018399.
  • 10. Johnson EL, Krauss GL, Kucharska-Newton A, Albert MS, Brandt J, Walker KA, Yasar S, Knopman DS, Vossel KA, Gottesman RF. Dementia in late-onset epilepsy: The Atherosclerosis Risk in Communities study. Neurology; 2020: 95(24): e3248-e3256.
  • 11. Koton S, Schneider ALC, Windham BG, Mosley TH, Gottesman RF, Coresh J. Microvascular brain disease progression and risk of stroke: The ARIC Study. Stroke; 2020: 51(11): 3264-3270.
  • 12. Palta P, Heiss G, Sharrett AR, Gabriel KP, Walker K, Evenson KR, Knopman D, Mosley TH, Wong D, Gottesman RF. Mid- and late-life leisure-time physical activity and global brain amyloid burden: the Atherosclerosis Risk in Communities (ARIC)-PET Study. Journal of Alzheimer’s Disease; 2020: 76(1): 139-147.
  • 13. Levine DA, Gross AL, Briceño EM, Tilton N, Kabeto MU, Hingtgen SM, Giordani BJ, Sussman JB, Hayward RA, Burke JF, Elkind MSV, Manly JJ, Moran AE, Kulick ER, Gottesman RF, Walker KA, Yano Y, Gaskin DJ, Sidney S, Yaffe K, Sacco RL, Wright CB, Roger VL, Allen NB, Galecki AT. Blood pressure and later-life cognition in blacks and whites (BP-COG): A pooled cohort analysis of ARIC, CARDIA, CHS FOS, NOMAS. JAMA Neurology; 2020: 77(7): 1-10.
  • 14. Gottesman RF, Mosley TH, Knopman DS, Hao Q, Wong D, Wagenknecht LE, Hughes TM, Qiao Y, Dearborn J, Wasserman BA. Intracranial atherosclerotic disease and brain Beta-amyloid deposition: the ARIC study. JAMA Neurology; 2019: 77(3): 350-357.
  • 15. Johansen MC, Mosley TH, Knopman DS, Wong DF, Wagenknecht LE, Shah AM, Solomon SD, Gottesman RF. Associations between left ventricular structure, function, and cerebral amyloid: The ARIC-PET study. Stroke; 2019: 50(12): 3622-3624.
  • 16. Schneider ALC, Selvin E, Liang M, Latour L, Turtzo LC, Koton S, Coresh J, Mosley T, Whitlow CT, Zhou Y, Wong DF, Ling G, Gottesman RF. Association of head injury with brain amyloid deposition: The ARIC-PET study. Journal of Neurotrauma. 2019: 36(17): 2549-2557.
  • 17. Power MC, Rawlings A, Sharrett AR, Bandeen-Roche K, Coresh J, Ballantyne CM, Pokharel Y, Michos ED, Penman A, Alonso A, Knopman D, Mosley TH, Gottesman RF. Association of midlife lipids with 20-year cognitive change: a cohort study. Alzheimer's and Dementia; 2018: 14(2): 167-177.
  • 18. Gottesman RF, Albert M, Alonso A, Coker LH, Coresh J, Davis SM, Deal JA, McKhann GM, Mosley TH, Sharrett AR, Schneider ALC, Windham BG, Wruck LM, Knopman DS. Associations between midlife vascular risk factors and 25-year incident dementia in the Atherosclerosis Risk in Communities (ARIC) cohort. JAMA Neurology; 2017: 74(10): 1246-1254.
  • 19. Gottesman RF, Schneider ALC, Zhou Y, Coresh J, Green E, Gupta N, Knopman DS, Mintz A, Rahmim A, Sharrett AR, Wagenknecht LE, Wong DF, Mosley TH. Association between midlife vascular risk factors and estimated brain amyloid deposition. JAMA; 2017: 317(14): 1443-1450.
  • 20. Gottesman RF, Schneider ALC, Zhou Y, Chen X, Green E, Gupta N, Knopman DS, Mintz A, Rahmim A, Sharrett AR, Wagenknecht LE, Wong DF, Mosley TH. The ARIC-PET Amyloid Imaging Study: Brain Amyloid Differences by Age, Race, Sex, and APOE. Neurology; 2016: 87(5): 473-480.