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Senior Investigator

Satoshi Ikemoto, Ph.D.

Building 251
251 Bayview Boulevard Suite 200
Baltimore MD 21224
Office: (443) 740-2722

Dr. Ikemoto received his PhD from Bowling Green State University for studying neuropharmacological mechanisms of reward and received postdoctoral training in animal models of drug self-administration at Indiana University School of Medicine and Louisiana State University School of Medicine. He joined the Behavioral Neuroscience Research Branch at NIDA as Research Fellow in 1998 and became a Tenure-track Investigator in 2004 and Senior Investigator in 2010. Dr. Ikemoto's research focuses on neurobiological mechanisms of motivation and reinforcement, using neuropharmacological, electrophysiological and electrochemical approaches. He is particularly interested in defining brain reward circuitry with respect to neurotransmitters, regions and connectivity. He also seeks to elucidate theoretical (conceptual) issues on functions of dopamine and related systems in motivated behaviors.

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  • 1) Wang DV, Viereckel T, Zell V, Konradsson-Geuken Å, Broker CJ, Talishinsky A, Yoo JH, Galinato MH, Arvidsson E, Kesner AJ, Hnasko TS, Wallén-Mackenzie Å, Ikemoto S (2017)
  • Disrupting glutamate co-transmission does not affect acquisition of conditioned behavior reinforced by dopamine neuron activation
  • Cell Reports , 18:2584-2591
  • 2) Wang DV, Ikemoto S (2016)
  • Coordinated interaction between hippocampal sharp-wave ripples and anterior cingulate unit activity
  • The Journal of Neuroscience, 36, 10663-10672
  • 3) Wang DV, Yau HJ, Broker CJ, Tsou JH, Bonci A, Ikemoto S (2015)
  • Mesopontine median raphe regulates hippocampal ripple oscillation and memory consolidation
  • Nature Neuroscience, 18, 728-735
  • 4) Ikemoto S, Yang C, Tan A (2015)
  • Basal ganglia circuit loops, dopamine and motivation: A review and enquiry
  • Behavioural Brain Res In press, 290, 17-31
  • 5) Keller KL, Vollrath-Smith FR, Jafari M, Ikemoto S (2014)
  • Synergistic interaction between caloric restriction and amphetamine in food-unrelated approach behavior of rats
  • Psychopharmacology, 231:825-840
  • 6) Ikemoto S, Bonci A (2014)
  • Neurocircuitry of drug reward
  • Neuropharmacology, 76 Pt B:329-341
  • 7) Ilango A, Kesner AJ, Keller KL, Stuber GD, Bonci A, Ikemoto S. (2014)
  • Similar roles of substantia nigra and ventral tegmental dopamine neurons in reward and aversion
  • The Journal of Neuroscience , 34, 817-22
  • 8) Jhou TC, Good CH, Rowley CS, Xu S, Wang H, Burnham NW, Hoffman AF, Lupica CR, Ikemoto S. (2013)
  • Cocaine drives aversive conditioning via delayed activation of dopamine-responsive habenular and midbrain pathways
  • Journal of Neuroscience , 33, 7501-7512
  • 9) Jhou TC, Xu SP, Lee MR, Gallen CL, Ikemoto S (2012)
  • Mapping of reinforcing and analgesic effects of the mu opioid agonist Endomorphin-1 in the ventral midbrain of the rat
  • Psychopharmacology, 224:303-312
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