Neuroscience@NIH > Faculty

Senior Investigator

Steven S. Vogel, Ph.D.

Laboratory of Molecular Physiology
Room TS-06F

5625 Fishers Lane MSC9411
Rockville MD 20892-

Office: (301) 496-9288
Lab: (301) 496-9288

stevevog@mail.nih.gov

Dr. Vogel received his B.S. from the City College of New York in 1978 and his Ph.D. from Columbia University in 1989, where he studied G-proteins in the nervous systems of Aplysia and squid with Jimmy Schwartz. During a postdoctoral fellowship with Josh Zimmerberg at NIDDK and NICHD, he investigated the calcium dependence of exocytosis in sea urchin eggs and discovered heterogeneity for calcium responses in a population of secretory vesicles. Dr. Vogel next became an assistant and subsequently a tenured associate professor at the Medical College of Georgia (1997-2003), where he studied the mechanism of exocytosis - endocytosis coupling. He joined NIAAA as an investigator in 2003, and became a senior investigator in 2013. His laboratory develops new fiber optic and microscope-based assays using FRET, fluorescence polarization, and fluorescence correlation spectroscopy to study protein-protein interactions in living cells, focusing on the structure and function of CaMKII holoenzyme.

1) G. Cui, S. Jun, X. Jin, M.D. Pham, S.S. Vogel, D.M. Lovinger, and R.M. Costa (2013)

Concurrent activation of striatal direct and indirect pathways during action initiation
Nature, 494, 238-242

2) T.A. Nguyen, P. Sarkar, J.V. Veetil, S.V. Koushik, and S.S. Vogel (2012)

Fluorescence polarization and fluctuation analysis monitor subunit proximity, stoichiometry, and protein complex hydrodynamics
PLoS One, 7, e38209

3) J. F. Covian-Nares, S.V. Koushik, H.L. Puhl III, and S.S. Vogel (2010)

Membrane wounding triggers ATP release and dysferlin-mediated intercellular calcium signaling
J Cell Science , 123, 1884-1893

4) S.S. Vogel (2009)

Channeling Calcium: A shared mechanism for exocytosis-endocytosis coupling
Science Signaling , 2, pe80

5) C. Thaler, S.V. Koushik, H.L. Puhl III, P.S. Blank, and S.S. Vogel (2009)

Structural rearrangement of CaMKII-alpha catalytic domains encodes activation
Proc Natl Acad Sci U S A, 106, 6369-6374

6) S. V. Koushik, H. Chen, C. Thaler, H.L. Puhl III, and S.S. Vogel (2006)

Cerulean, Venus and VenusY67C FRET reference standards
Biophysical Journal, 91, L99-101

7) S S. Vogel, C. Thaler, and S.V. Koushik (2006)

Fanciful FRET
Science STKE, ,re2

8) C. Thaler, S.V. Koushik, P.S. Blank, and S.S. Vogel (2003)

Quantitative Multiphoton Spectral Imaging and its use for Measuring Resonance Energy Transfer
Biophysical Journal , 89, 168-72

9) R. M. Smith, B. Baibakov, Y. Ikebuchi, B. H. White, N. A. Lambert, L. K. Kaczmarek, and S. S. Vogel (2000)

Exocytotic Insertion of Calcium Channels Constrains Compensatory Endocytosis to Sites of Exocytosis
The Journal of Cell Biology, 148, 755-767

10) S.S. Vogel, R. M. Smith, B. Baibakov, Y. Ikebuchi, and N. A. Lambert (1999)

Calcium influx is required for endocytotic membrane retrieval
Proc. Natl. Acad. Sci., USA, 96, 5019-5024

11) S. S. Vogel, P. S. Blank, & J. Zimmerberg (1996)

Poisson distributed active fusion complexes underlie the control of the rate and extent of exocytosis by calcium
The Journal of Cell Biology, 134, 329-338

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