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Senior Investigator

Victor W. Pike, Ph.D.

Molecular Imaging Branch
Building 10 Room B3-C346
10 Center Drive MSC1003
Bethesda MD 20892-1003
Office: (301) 594-5986

Fax: (301) 480-5112

Dr. Pike received his B.Sc. in chemistry from the University of Birmingham (UK) in 1972 and his Ph.D. in organic chemistry from the same University in 1975. Following a postdoctoral fellowship at Birmingham University, he joined the MRC Cyclotron Unit (London) in 1978 at the foundation of its strong research program in positron emission tomography (PET), eventually becoming Head of its Chemistry and Engineering Section. Throughout his career Dr. Pike has had a strong interest in all chemical aspects of the discovery, development and evaluation of novel radioactive probes for molecular imaging with PET. Dr. Pike was awarded the Marie Curie Award in 1995 and Springer Prize in 1999 for his work in this area. He joined the Molecular Imaging Branch of NIMH as a Senior Investigator in 2001. His laboratory develops novel radioactive probes for the investigation of neuropsychiatric disorders with PET.

The core scientific interest of this Section is to invent and implement new radioactive probes (radiopharmaceuticals) for imaging specific molecular targets (e.g. neurotransmitter receptors, transporters or enzymes) in animal and human brain with positron emission tomography (PET). These probes are vital for PET investigations of the underlying causes of neuropsychiatric illness and the mechanisms and efficacies of existing or proposed treatments.

The main activities of this Section are i) medicinal/organic chemistry aimed at the discovery and synthesis of candidate probes (usually based on small drug-like organic molecules), ii) radiochemistry for the rapid labeling of these candidates with short-lived cyclotron-produced positron-emitters (e.g., carbon-11, t1/2 = 20 min and fluorine-18, t1/2= 110 min), iii) evaluation of the efficacy of the radioactive probes in vivo, including characterization of their metabolism, and iv) the regular production of successful probes for PET experiments in animals and humans. For the evaluation of novel PET probes in animal and human subjects and for their implementation in clinical research studies, the Section interacts seamlessly with the Imaging Section of the Molecular Imaging Branch, led by Dr. Bob Innis.

In support of the main mission of PET radiotracer development, the Section also undertakes research on advancing the methodology of PET radiochemistry, and of radiometabolite measurement and identification.

Staff Image
  • Chad Brouwer, Ph.D.
    Postdoctoral Fellow
    (301) 451-3913

  • Lisheng Cai, Ph.D.
    Staff Scientist
    (301) 451-3905

  • Joong-Hyun Chun, Ph.D.
    Postdoctoral Fellow

  • William Culligan, B.S.
    Post baccalaureate Fellow

  • Jinsoo Hong, Ph.D.
    (301) 451-3929

  • Shuiyu Lu
    Staff Scientist
    (301) 451-3904

  • Cheryl Morse, M.S.
    Contract Chemist
    (301) 451-3910

  • Gregory Naumiec, Ph.D.
    Postdoctoral Fellow
    (301) 451-3912

  • C. Nolton
    (301) 435-7847

  • Kun Park, M.S.
    Research Assistant
    (301) 451-9408

  • Umesha Shetty, Ph.D.
    Contract Chemist
    (301) 451-3923

  • Fabrice Simeon, Ph.D.
    Staff Scientist

  • Sanjay Telu, Ph.D.
    Postdoctoral Fellow
    (301) 451-3930

  • Yi Zhang, Ph.D.
    Contract Chemist
    (301) 451-3928

  • 1) Hume S., Hirani E., Opacka-Juffry J., Myers R., Townshend C., Pike V. and Grasby P. (2001)
  • Effect of 5-HT binding of [11C]WAY-100635 to 5-HT1A receptors in rat brain, assessed using in vivo microdialysis and PETafter fenfluramine
  • Synapse, 41, 150-159
  • 2) Glaser M., Brown D.J., Law M.P., Iozzo P., Waters S.L., Poole K., Knickmeier M., Camici P.G. and Pike V.W. (2001)
  • Preparation of no-carrier-added [124I]A14-iodoinsulin as a radiotracer for positron emission tomography
  • J. Label. Compd Radioparm., 44, 465-480
  • 3) Constantinou C., Aigbirhio F.I., Smith R.G., Ramsden C.A. and Pike V.W. (2001)
  • [18F]Xenon difluoride exchanges fluoride under mild conditions - a simple preparation of [18F]xenon difluoride for PET and mechanistic studies
  • J. Am. Chem. Soc., 123, 1780-1781
  • 4) Marchais S., Nowicki B., Wikstrom H., Halldin C., Brennun L.T. and Pike V.W. (2001)
  • Short and efficient syntheses of analogues of WAY-100635; new and potent 5-HT1A receptor antagonists
  • Biorg. Med. Chem., 9, 695-702
  • 5) Sandell J., Halldin C., Pike V.W., et al. (2001)
  • New halogenated [11C]WAY analogues, [11C]6FPWAY and [11C]6BPWAY - radiosynthesis and assessment as radioligands for the study of 5-HT1A receptors in living monkey
  • Nucl. Med. Biol. , 28, 177 - 185
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