Senior Investigator
Yavin
Shaham,
Ph.D.
Behavioral Neuroscience Branch
Yavin Shaham, Ph.D., Branch Chief, Behavioral Neuroscience Branch and Section Chief, Neurobiology of Relapse Section, NIDA.
Ph.D.: 1992, Psychology, Uniformed Services University of the Health Sciences, Bethesda, Maryland
M.A.: 1988, Psychology, Hebrew University, Jerusalem, Israel
B.S.: 1986, Biology & Psychology, Hebrew University, Jerusalem, Israel
Dr. Shaham’s lab uses rat models to study the cellular and neuroanatomical mechanisms that underlie relapse to drug and aggression seeking. Working with the In-vivo Electrophysiology Unit led by Dr. Eugene Kiyatkin, the lab also studies neurophysiological mechanisms of addictive drugs and motivated behavior.
Current projects of the Shaham group:
- Incubation of drug craving after forced or voluntary abstinence
- Context-induced relapse to drug seeking after punishment or extinction
- Aggression addiction and relapse
Current projects of the Eugene Kiyatkin group (In-vivo Electrophysiology Unit):
- Physiological analysis of motivated behavior using single-unit recording, iontophoresis, EEG/EMG, brain thermorecording, and glutamate electrochemistry
- Neurophysiological and neurochemical mechanisms of action of drugs of abuse (cocaine, nicotine)
- Alterations in blood-brain barrier in normal brain functions and during drug intoxication
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1) Venniro M, Caprioli D, Zhang M, Whitaker LR, Zhang S, Warren BL, Cifani C, Marchant NJ, Yizhar O, Bossert JM, Chiamulera C, Morales M, Shaham Y (2017)
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The Anterior Insular Cortex→Central Amygdala Glutamatergic Pathway Is Critical to Relapse after Contingency Management
- Neuron, 2017 Oct 11;96(2):414-427.e8.
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2) Golden SA, Heins C, Venniro M, Caprioli D, Zhang M, Epstein DH, Shaham Y (2017)
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Compulsive Addiction-like Aggressive Behavior in Mice
- Biol Psychiatry, 2017 Mar 17. pii: S0006-3223(17)31359-8, doi: 10.1016/j.biopsych.2017.03.004
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3) Caprioli D, Venniro M, Zhang M, Bossert JM, Warren BL, Hope BT, Shaham Y (2017)
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Role of Dorsomedial Striatum Neuronal Ensembles in Incubation of Methamphetamine Craving after Voluntary Abstinence.
- J Neurosci, 2017 Jan 25;37(4):1014-1027. doi: 10.1523/JNEUROSC
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4) Bossert JM, Stern AL, Theberge FR, Marchant MJ, Wang HL, Morales M, Shaham Y (2016)
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Role of projections from ventral subiculum to nucleus accumbens shell in context-induced reinstatement of heroin seeking in rats
- Psychopharmacology (Berl), 2016 May;233(10):1991-2004. doi: 10.1007/s00213-01, Epub 2015 Sep 7
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5) Heilig M, Epstein DH, Nader MA, Shaham Y (2016)
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Time to connect: bringing social context into addiction neuroscience
- Nat Rev Neurosci, . 2016 Sep;17(9):592-9. doi: 10.1038/nrn.2016.67.
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6) Marchant NJ, Campbell EJ, Whitaker LR, Harvey BK, Kaganovsky K, Adhikary S, Hope BT, Heins RC, Prisinzano TE, Vardy E, Bonci A, Bossert JM, Shaham Y (2016)
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Role of Ventral Subiculum in Context-Induced Relapse to Alcohol Seeking after Punishment-Imposed Abstinence
- J Neurosci, 2016 Mar 16;36(11):3281-94. doi: 10.1523/JNEUROSCI
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7) Caprioli D, Venniro M, Zeric T, Li X, Adhikary S, Madangopal R, Marchant NJ, Lucantonio F, Schoenbaum G, Bossert JM, Shaham Y (2015)
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Effect of the Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 2 AZD8529 on Incubation of Methamphetamine Craving After Prolonged Voluntary Abstinence in a Rat Model
- Biol Psychiatry, 2015 Oct 1;78(7):463-73. doi: 10.1016/j.biopsych.2
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8) Li X, Rubio FJ, Zeric T, Bossert JM, Kambhampati S, Cates HM, Kennedy PJ, Liu QR, Cimbro R, Hope BT, Nestler EJ, Shaham Y (2015)
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Incubation of methamphetamine craving is associated with selective increases in expression of Bdnf and trkb, glutamate receptors, and epigenetic enzymes in cue-activated fos-expressing dorsal striatal neurons
- J Neurosci, 2015 May 27;35(21):8232-44, doi: 10.1523/JNEUROSCI.1022-15.2015
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9) Marchant NJ, Rabei R, Kaganovsky K, Caprioli D, Bossert JM, Bonci A, Shaham Y (2014)
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A critical role of lateral hypothalamus in context-induced relapse to alcohol seeking after punishment-imposed abstinence
- J Neurosci, . 2014 May 28;34(22):7447-57. doi: 10.1523/JNEUROS
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10) Bossert JM, Stern AL, Theberge FR, Cifani C, Koya E, Hope BT, Shaham Y (2011)
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Ventral medial prefrontal cortex neuronal ensembles mediate context-induced relapse to heroin
- Nat Neurosci, 2011 Apr;14(4):420-2, doi: 10.1038/nn.2758. Epub 2011 Feb 20
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